O'Neal, 41, was stricken last week, fellow comic Jim Norton announced on the "Opie and Anthony" satellite radio talk show, where O'Neal was a frequent guest, E! News reported.
"We don't know how he is. We don't know how he's going to be," said Norton. "I didn't want to do this by myself. I wish we had more news for you."
O'Neal was recently featured on a Comedy Central roast of friend Charlie Sheen. TMZ said Sheen released a statement calling O'Neal "a gentle giant, a brilliant comedian, and a noble dude."
"Wishing him nothing but recovery, healing and laughter," Sheen said.
A statement posted on Opie and Anthony's Facebook page said the family has set up an e-mail for fans to post their well-wishes.
"Our close friend Patrice O'Neal suffered a stroke last week," the statement said. "Please respect his family and their request for privacy. An e-mail has been set up for fans to send him well-wishes and his family will make sure he gets them. You can write to LoveForPatrice@gmail.com. When we have an update on his condition, we will let you all know."
Easer Egg Roll brings thousands to White House
Turkey considering to use pistachios to heat country’s first eco-city