The celebrity and entertainment news Web site did not identify a man and woman who were seen with the movers, but said two men loaded a couch and love seat and boxes for about an hour at the Seal Beach home of Bullock and her estranged husband Jesse James.
The New York Daily News reported that Bullock plans to file for divorce from James after his extramarital affairs became public.
"She is talking to her lawyer and definitely decided to file for divorce from Jesse. … She is over him," a friend of Bullock's told Us Weekly. "She won't forgive him for this."
Bullock praised James for "having her back" when she won the Golden Globe best actress award for "The Blind Side."
The trouble may just have begun for James, who has checked himself into an addiction rehab clinic.
Long Beach, Calif., police are investigating a Thursday altercation between James and a photographer broadcast on KTLA-TV, Los Angeles.
In the video, James screams at the photographer to leave the area near his business. The paparazzo claimed his tires had been slashed, The Los Angeles Times reported.
A Long Beach Police Department spokeswoman confirmed James was under investigation for vandalism and the photographer for stalking, KTLA-TV said.