The collection includes White's best known hits -- such as "I'm Gonna Love You Just a Little More, Baby," "Never, Never Gonna Give Ya Up," "Can't Get Enough of Your Love, Babe" and "You're the First, the Last, My Everything."
Universal Music Enterprises said the disc is to drop Sept. 15. White's birthday is Sept. 12.
He died July 4, 2003, after suffering a stroke and renal failure. He was 58.
"'Number Ones' brings together all of White's No. 1 hits as a solo artist and as leader of the instrumental ensemble Love Unlimited Orchestra plus his No. 1 production for his girl group Love Unlimited," the record label said. "Five bonus tracks that just missed the top spot and/or have become hip-hop sample favorites are also included."
In addition, "Unlimited" -- a 5-disc, limited-edition, career-spanning, rarities box set -- will be released Oct. 27, Universal said.