Jackson sings the song she co-wrote and co-produced with Jeffre Phillips.
A news release described the single as having been "written with affection about her childhood memories and based on the premise that no matter where you are or what you are going through in your life, you can always go 'home.'"
Her record label said it had planned to release another single from Jackson's forthcoming album at this time, but with the death of her brother, Michael, last month, decided it would be a positive gesture to release "Home" instead.
"We felt that to move forward releasing La Toya's album as planned without recognizing Michael's tragic passing was inappropriate," Bungalo President Paul Ring said in a statement. "After consulting with La Toya, we decided that both Bungalo and Ja-Tail Records would not earn any profit, but rather donate all of our time, energy, and proceeds to one of MJ's favorite charities, APLA. We feel that the song and La Toya are amazing and to be able to raise awareness and funds for this organization is exactly what Michael would have approved of."