Rourke, 56, earned top guy honors, while fellow actor Clint Eastwood was given a Brass Balls Award Saturday night at the Sony Studios in Los Angeles, the U.S. cable network said in a news release.
The third annual Spike TV awards show also found Cleveland Cavaliers star LeBron James winning the event's Most Unstoppable award and actress Angelina Jolie recognized with a best Femme Fatale award.
Meanwhile, film producer Judd Apatow, known for such movies as "Superbad" and "Pineapple Express," received a Man Kind Award.
Other top winners included actress Halle Berry, who was given a Decade of Hotness award; "Borat" comedian Sacha Baron Cohen, presented the Funniest M.F. award; and singer Katy Perry, named Sexiest Siren.
Spike TV said the show also paid tribute to "Fight Club." The film's stars, Brad Pitt and Edward Norton, along with director David Fincher, helped induct the violent movie into the Guy Movie Hall of Fame.