The new shows include three dramas and one comedy.
O'Donnell and LL Cool J will star in "NCIS: Los Angeles," a spinoff from the hit drama "NCIS."
"The Good Wife" stars Margulies, an Emmy Award winner, in a legal drama about a steadfast wife and mother who boldly returns to work as a lawyer when her husband is imprisoned for a high-profile political scandal.
"Three Rivers" is a medical drama starring Alex O'Loughlin as the head of a renowned transplant surgery team and "Accidentally On Purpose" stars Elfman, a Golden Globe Award winner, in an ensemble comedy about a successful, single journalist who accidentally gets pregnant by a much younger man.
Returning to the CBS schedule will be "Two and a Half Men," "The Mentalist," "60 Minutes," "Survivor," "The Amazing Race," "The Big Bang Theory," "How I Met Your Mother," "CSI: Miami," "NCIS," "The New Adventures of Old Christine," "Gary Unmarried," "Criminal Minds," "CSI: NY," "Ghost Whisperer," "NUMB3RS," "48 Hours Mystery" and "Cold Case."
Ordered for midseason is a new fast-paced medical drama from executive producer Jerry Bruckheimer, "Miami Trauma," the new police drama "The Bridge," the returning comedy "Rules of Engagement," and the new alternative series "Arranged Marriage" and "Undercover Boss."
CBS also said it plans to add the drama series "Medium" to its lineup next season. The show, starring Emmy Award winner Patricia Arquette, was canceled by NBC this week.
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