Rivers beat out world champion poker player Annie Duke Sunday night in the business-themed reality show's 3-hour finale.
The finalists' last challenge had them reunite with various "Apprentice" castoffs to organize separate auctions for their favorite charities.
"Apprentice" star and executive producer Donald Trump noted the competition was about more than who raised the most money, it was about how the women played the game.
"Your level of strength, your level of energy have just been amazing," Trump told Rivers, 75. "You really are a role model for so many people... Annie, you're fired. Joan, congratulations."
Rivers, her daughter Melissa, Herschel Walker and Clint Black raised $150,830 for God's Love We Deliver in the final challenge, the New York Daily News said.
Duke, Dennis Rodman, Tom Green and Brande Roderick raised $465,725 for Refugees International.