The couple were married for 14 years and had three children together. The family lives in upstate New York.
"My wife was an extraordinary person who showed us all what great strength is," Tucci told the New York Post.
A wake was held for Kate Tucci last weekend, the Post said Thursday.
Stanley Tucci has appeared in dozens of films, including "Prizzi's Honor," "It Could Happen to You," "America's Sweethearts," "Maid in Manhattan" and "The Devil Wears Prada."