Previous seasons of the show aired on Bravo. "Runway" is slated to premiere on Lifetime Aug. 20.
Host Heidi Klum, mentor Tim Gunn and judges Michael Kors and Nina Garcia will guide 16 new contestants as they show off their design skills to see who makes the cut for Fashion Week, Lifetime said in a news release.
Shot in Los Angeles and New York, "Project Runway" also features influential guest judges from the worlds of fashion, music, film and television.
"I am a huge fan of 'Project Runway' and could not be happier that Season 6 will be premiering on Lifetime, the No.1 network for women," Lifetime's Andrea Wong said in a statement. "The talent in this all-new season is nothing short of amazing, and I can't wait for all of the fans to see the incredible work of these brilliant designers."