McCartney will be joined on stage at the April 4 charity concert by special guests such as his fellow former Beatle Ringo Starr, Sheryl Crow, Donovan, Eddie Vedder, Ben Harper, Moby, Paul Horn, Bettye LaVette and Jim James, organizers said.
Tickets are to go on sale Monday through www.ticketmaster.com.
Fillmaker David Lynch, hip-hop mogul Russell Simmons, actress Laura Dern, and other surprise guests are to fill out the star-studded slate as presenters.
The "Change Begins Within" concert is being held to raise funds to teach 1 million at-risk children to meditate -- giving them life-long tools to overcome stress and violence and promote peace and success in their lives, the foundation said.
In 1968, the Beatles, Donovan, and Paul Horn traveled to India to study Transcendental Meditation with Maharishi Mahesh Yogi. The trip's dramatic impact was evident in their music and is credited for the acceptance of meditation in the West today, the organization said.
"In moments of madness, it has helped me find moments of serenity," McCartney said about meditation in a news release.
He added that he supports the work of the David Lynch Foundation to bring the technique to children for the same reason.
"I would like to think that it would help provide them a quiet haven in a not-so-quiet world," he said.