Arquette, best known for her work on the supernatural drama series "Medium," cited irreconcilable differences as the reason for the split, the entertainment news Web site said.
Jane has starred in the films "The Punisher" and "The Mist."
The couple are the parents of a 5-year-old daughter.
McPhee, Cokas 'working on their marriage' after affair
Ohio bar shooting arrested, charged with murder