Keys was nominated for Favorite Female Artist in both the Pop/Rock and Soul/R&B categories, earned two Favorite Album nominations for her album "As I Am" in the Pop/Rock and Soul/R&B categories and garnered a nod for Artist of the Year.
Coldplay and The Eagles each were nominated for four awards.
"2008 American Music Awards" host Jimmy Kimmel, and recording artists Julianne Hough and Jesse McCartney announced the nominees Tuesday morning at the Beverly Hills Hotel.
Rihanna, Ne-Yo, Taylor Swift, Pussycat Dolls, New Kids on the Block, P!nk and Jonas Brothers are slated to perform at the 36th annual event. Additional acts and presenters will be announced in the coming weeks, ABC said.
The live broadcast is scheduled to take place at the NOKIA Theatre in Los Angeles Nov. 23.
For the second year, winners will be determined by online voting at amavote.com, the network said.
"From our nominees to performances to Jimmy Kimmel's humor, this year's AMAs is sure to be a great evening," Larry Klein, AMA producer, said in a statement. "The show is a true reflection of popular culture and what is current to consumers of live and recorded music."