Aniston won an Emmy for her work on "Friends," the former NBC sit-com she called home for a decade.
She is to appear in one episode of "30 Rock" as the "free-spirited, 'Fatal Attraction'-like stalker Claire Harper, Liz Lemon's (Tina Fey) former roommate from Chicago who randomly shows up in New York and attaches herself to Jack Donaghy (Alec Baldwin,)" the network said in a news release.
The announcement was made Tuesday by Teri Weinberg, executive vice president of NBC Entertainment.
"What a thrill to have Jennifer back on NBC on a Thursday night. She is the perfect comedic talent to work with the Emmy-winning '30 Rock' cast," Weinberg said in a statement. "This promises to be a memorable, hilarious night of comedy."
"Jennifer is not only incredibly lovely to have around, she also has what the young people would call 'mad skills.' We're very excited that she's joining us," added Fey, creator, executive producer and star of "30 Rock."
Aniston's movie credits include "Bruce Almighty," "Along Came Polly," "The Good Girl" and "The Break-Up."
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