Lil Wayne and the Jonas Brothers were previously announced as performers at the 25th annual event Sept. 7.
British comedian and actor Russell Brand is to serve as host of the awards ceremony.
Presenters and additional performers are to be announced at a later date, MTV said.
Rock made headlines when he and Tommy Lee got into a fight during last year's VMAs.
Disney's 'Jessie' to feature network's first engagement
Members of Congress to keep receiving porn magazine