Parker is the comic book character who changes into the superhero Spider-Man to battle evil.
The musical will feature music and lyrics by Bono and The Edge of U2.
The creative team behind the show is looking for a Peter Parker aged 16-20s, with a great rock voice, who can be "nerdy" with "understated sex appeal" and who has a good sense of humor. The want a Mary Jane actress aged 16-20s, a "beautiful girl next door" type with strong pop/rock singing voice; and a principal woman who is female, aged 25-35 with "amazing rock vocals," who is something like "Sinead O'Connor with a Middle Eastern /Bulgarian/Greek/ twist."
The open call is scheduled for July 28 from 10 a.m. to 5 p.m. at The Knitting Factory in Manhattan.
Those wishing to audition should prepare 16 bars of a pop/rock song that shows his or her range, and bring sheet music, as well as a photo and resume if they have one, the producers said.