Blair, who also starred in "Legally Blonde" and "Cruel Intentions," was recently asked by reporters in Los Angeles how her career and life were affected by the original blockbuster.
"After the first 'Hellboy,' I loved that movie, but my life didn't really change that much with work," Blair explained before "Hellboy II: The Golden Army" was released last weekend and became the No. 1 movie at the U.S. box office.
"We all kind of stayed as we are, as our characters -- this sort of underground group of misfit actors. It was great getting back to work. I loved it. It was like being back with family again," Blair said of her co-stars Ron Perlman and Doug Jones. "It was amazing to be back with (director) Guillermo (del Toro.) I think this movie outdoes the first one. The scope of it is huge and to all be away on location in Budapest for six months, we all looked after each other really well. I know they all looked after me."