The movie's cast also includes Christine Taylor, Conchata Ferrell, Chris Parnell and writer/director/actor Scott Prendergast.
The film is based on Prendergast's personal experiences as a bad babysitter for his brother's children, said a release issued by Whitewater Films and Regent Releasing.
In "Kabluey," Kudrow plays the mother of two young boys, trying to hold things together while her husband's National Guard unit is fighting in Iraq.
Desperate for some help, she allows her husband's brother, played by Prendergast, to move in and act as nanny. However, his parenting skills are lacking and mayhem ensues.
"Kabluey" is to open July 4 in New York; July 11 in Los Angeles; July 25, in Austin, Texas; and Aug. 1 in San Francisco.
Notable deaths of 2014 [PHOTOS]