O'Hurley is best known for his stints on "Seinfeld," "Dancing with the Stars" and "Family Feud."
Entertainer Debbie Reynolds, singer Brian McKnight and movie producer Gavin Polone are set to judge the weekly performances on the series, which is to premiere Tuesday.
Celebrities will compete each week in a tournament-structured format to determine who has the best unknown talent. Each performance will be critiqued by Reynolds, McKnight and Polone, but the viewers get to vote for the celebrity who impresses them the most, and determine which stars move on in the competition, CBS said.
The lineup also includes wrestler Ric Flair, boxing great Joe Frazier, Playboy Playmate Bridget Marquardt, singer Mya, actor Danny Bonaduce, musician Sheila E., boxer Roy Jones Jr., model Cindy Margolis and political pundit Ben Stein.