The campaign, Chalke's first with Hanes, will include television spots directed by her "Scrubs" co-star Zach Braff.
"I am so glad that Hanes is conquering the dreaded wedgie because it can happen at any time to anyone," Chalke said in a statement. "For my first appearance at the Emmys, which was also my first time on the red carpet, I chose a gorgeous dress, but made a bad underwear selection. There were cameras everywhere so I had no opportunity to fix anything, especially a wedgie. Now I wear my No Ride Up panties because I love how they fit and I don't have to worry about tugging them back into place."
"We wanted to address women's number one panty complaint with humor and candor, while providing an easy and comfortable solution," Sidney Falken, senior vice president of Hanes, said in a statement. "Sarah's uncanny knack for physical comedy and her approachable personality ... make her the perfect person to engage other women and ignite conversation about this campaign while reinforcing our brand's comfort fit promise."