The show was conceived by Sprint, Suave and MindShare Entertainment and is set to return to MSN this month. It will also be available on suave.com, sprint.com and the Sprint Exclusive Entertainment network
The scripted, short-form Web series, which was viewed 5.5 million times last season, is about the hectic lives of mom girlfriends, inspired by stories submitted by real-life mothers and voted on by the online mom community.
The chosen stories are then polished by the show's professional writing team and developed into Web-based films.
This year, consumers who write the winning submissions will be invited to the filming, so they can meet the actresses and see their stories come to life.
"Every mom, including myself, can relate to the hilarious scenarios that arise throughout 'In the Motherhood,' because the story lines capture an authentic look at the lives of real moms," McCarthy said in a statement. "It's so much fun to be part of a series that perfectly encapsulates these comical situations that only another mom would understand."