The New York Post said the suspects fired more than a dozen shots at the Staten Island home Barja Walter shares with his girlfriend and three children, as well as at his bulletproof sports utility vehicle.
The perpetrators also threw a Molotov cocktail on his lawn, police sources told the newspaper.
No one was injured in the early Tuesday incident.
The Post said its calls to Walter's attorney and 50 Cent's representatives were not returned.
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