Senior U.S. District Judge William Terrell Hodges this week rejected a request by Snipes' lawyers to move the trial to a venue outside Marion County. The attorneys had claimed that Ocala was too racist for the black film star to get a fair trial.
Hodges also denied a motion to postpone the trial, which is scheduled to start Jan 14.
"We're pleased with the judge's decision and we're ready to go to trial," said Steve Cole, a spokesman for the U.S. Attorney's Office in Tampa, Fla.
Snipes' lawyers could not be reached for comment, the Star-Banner said.
The actor best-known for starring in the "Blade" trilogy -- as well as "Murder at 1600," "White Men Can't Jump" and "Jungle Fever" -- pleaded innocent last year to federal tax charges.
He was indicted in October 2006 on charges he tried to collect more than $11 million in allegedly fraudulent tax refunds, and quit filing altogether in 1998.