The film's female star Katherine Heigl made headlines recently when she was quoted in a Vanity Fair interview suggesting the film is sexist. The "Grey's Anatomy" actress later clarified her remarks, saying she had a great experience making the movie.

Asked about her remarks, Apatow, who wrote and directed "Knocked Up," told E! Online: "I think the characters are sexist at times. But it's really about immature people who are afraid of being in a relationship and how they evolve out of that and learn how to be parents and how to grow up. So, if people say it's sexist, yeah, that's what I was going for in the first part of the movie. But then (the characters) change."

Apatow also said he understood how remarks can sometimes be taken out of context, however, E! Online said that while Apatow seemed calm and relaxed in making the statements, he said, "No" and made an unpleasant face when asked if he had spoken to Heigl since her interview came out.