The popular series ended in 2004 and Cox, a married mother of a 3-year-old girl, has since gone on to star in the series "Dirt."
Asked if she thinks there is a chance for a "Friends" reunion, Cox told Us Weekly: "I don't think so. But I would never say 100 percent no."
Cox also offered some thoughts about what her "Type A" personality character, Monica Geller-Bing, and the character's fictional husband, Chandler Bing, might be doing right now.
"She's running her suburb and in charge of the PTA," Cox said. "She's driving Chandler crazy, and he's probably driving her crazy, too."