"I have a feeling this will be the end (for the current stars). This franchise may move to another generation," Ortega told the magazine.
While the first two movies were made for the small screen, the third film is expected to get a theatrical release in October.
"It's their senior year, so there's going to be graduation -- and prom," "HSM" veteran Vanessa Hudgens revealed.
Kate Middleton recycles dress at movie premiere
Gal Gadot cast as Wonder Woman for 'Batman vs. Superman'