Ripa's co-host Regis Philbin joked on Wednesday's show that Ripa -- the mother of three -- was suffering from morning sickness.
Ripa returned to work Wednesday after getting sick Tuesday.
"I've got my own theories, and let me tell you: She's pregnant again!" Philbin said on Wednesday's show. "I've been through it twice now."
"No, no," Ripa replied. "That would be nice, though. Wouldn't that be nice?"
Ripa won't be on Thursday's "Live!" because Philbin taped a second show immediately after Tuesday's program with his wife, Joy, as co-host, People.com said.