At 56, Seymour was the oldest female contestant ever to compete on the show, People.com noted.
The "Wedding Crashers" and "Dr. Quinn, Medicine Woman" star was the seventh contestant eliminated this season. She left the show Tuesday night.
During her stint on the show, Seymour's mother died, her house was threatened by the California wildfires and she suffered from food poisoning.
Still, the experience was "so worth doing," Seymour told People after the show.
"I think we had an incredible run," she said.
"Every week, we had challenges and each week she prevailed," said Seymour's partner, Tony Dovolani. "Regardless of the outcome (Tuesday night) she's won because she represented women of all ages out here. She's one of the greatest people I've ever met in my life."