The "Bat Out of Hell" singer, whose real name is Michael Lee Aday, canceled the show at the MEN Arena after reportedly being told not to perform by his doctor, the BBC said.
The canceled concert marked the second straight last-minute cancellation by the U.S. singer, who was forced to call off another show in the city of Birmingham last Friday.
The "Paradise By the Dashboard Light" star also was forced to end his concert at Newcastle's Metro Radio Arena early after his illness flared up.
Witnesses to that concert said the 60-year-old even said that the Three Bats Tour performance may ultimately prove to be his last live concert, the BBC reported.
Yet Meat Loaf's promoters quickly dismissed such notions, saying the singer was simply exhausted and would continue on with his tour of Britain.