Also joining the cast is "Breaking and Entering" and "The Princess Bride" actress Robin Wright Penn, Variety.com reported Tuesday.
Miller, whose films include "Personal Velocity" and "The Ballad of Jack and Rose," is the daughter of late playwright Arthur Miller, who wrote the drama, "The Crucible." Ryder starred in the 1996 film version of "The Crucible," alongside Rebecca Miller's husband, Daniel Day-Lewis.
"Pippa Lee" is a drama-comedy about a put-upon wife whose husband falls for a younger woman, paving the way for "a very quiet nervous breakdown, the trade paper said.
Miller is slated to begin shooting the film in April in Connecticut.
Ryder has starred in "The Age of Innocence," "Bram Stoker's Dracula," "Little Women," "Reality Bites" and "Girl, Interrupted."
Moore is known for her roles in "Children of Men," "The Hours," "Hannibal" and "An Ideal Husband."