Goodman, who has appeared in numerous Boston-set films since the 1990s, wrote the screenplay for "Real Men" with fellow Boston natives Donnie Wahlberg and Paul T. Murray, The Hollywood Reporter said.
The film was inspired by actual people and events in Goodman's life.
In the movie, Hawke and Ruffalo will play childhood friends and small-time crooks in South Boston.
"I sat down with Mark and Ethan and told them, 'You are two on a very short list of men who could've been in films 35 years ago, when men were men,'" Goodman told the trade paper.
Peet has been cast as the wife of Ruffalo's character.
Toddler uninjured after being knocked over by Obama family dog
Martin Bashir resigns from MSNBC over Sarah Palin comments