To be directed by Pam MacKinnon, the Signature Theatre Company production is to run at The Peter Norton Space in Manhattan from May 6-June 29.
Albee, the author of "Who's Afraid of Virginia Woolf?" "Tiny Alice," "A Delicate Balance," "Three Tall Women" and "Seascape,"was Signature’s 1993-94 playwright-in-residence.
"Occupant" is a portrait of acclaimed sculptor Louise Nevelson that explores the nature of the relationship between creator and creation. Ruehl will play Nevelson, representatives for the show said in a statement.
Ruehl last appeared on the New York stage in Albee's "The Goat, or Who is Sylvia?"
She has also starred in the films "The Fisher King," "Married to the Mob," "Big," "The Secret of My Success" and "Slaves of New York."