Messing, who is best-known for playing Grace on the NBC comedy, "Will & Grace," is set to star in and executive produce the new show, which was inspired by The New York Times best-selling novel by Gigi Levangie Grazer.
Grazer will also serve as executive producer on the life-after-divorce comedy, which follows Molly Kagan as she redefines herself after years of marriage to a Hollywood studio head.
The original miniseries earned 10 Emmy nominations.
"'The Starter Wife' was a major cultural event, and an out-of-the-park home run for us," Jeff Wachtel, executive vice president of original programming for USA, said in a statement. "We're thrilled to reunite Debra, Josie (McGibbon,) Sara (Parriott) and Gigi -- the world-class team of star and writers who were responsible for its success."
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