The premier was Wilson's first major public appearance since he reportedly tried to commit suicide in August.
Although he did not chat with reporters on the red carpet, Wilson was greeted with applause when he joined his co-stars Adrien Brody, Jason Schwartzman and Anjelica Huston on-stage before the screening, People.com reported Friday.
Describing Wilson as "my best friend," director Wes Anderson told the audience, "I've never made a movie without him and I hope I never have to."
"I have to say, I have a crush on Owen," Huston told People.com before Wilson joined her for a few moments in the front row, then exited the theater before the screening began.
Huston has also worked with Wilson on Anderson's films "The Royal Tenenbaums" and "The Life Aquatic."
Wilson did not make any comments or field any questions about either the movie or his personal life at the premiere, E! News said.
Following his hospitalization during the summer, the actor has kept a low profile, canceling promotional appearances for the film, including its world premiere at the Venice Film Festival last month.