Clapton headlined the show, hosting former Blind Faith bandmate and Traffic leader Steve Winwood and The Band's Robbie Robertson during his set and also jamming with Sonny Landreth and with a consortium of Sheryl Crow, Vince Gill and Albert Lee. Other performers included Jeff Beck, Buddy Guy, B.B. King, John Mayer, Willie Nelson and Alison Krauss & Union Station.
Comedian Bill Murray, a Chicago native, hosted the event, appearing in a series of costumes that mimicked Clapton's looks over the years.
The festival, a follow-up to Clapton's 2004 event in Dallas, raises money for Clapton's Crossroads Centre rehabilitation facility in Antigua.