A representative for Cryer confirmed that the couple tied the knot on Saturday, People magazine reported.
"They're very, very happy," said the rep.
Cryer, 41, announced that he and Joyner, the host of TV Guide's "InFANity," were engaged on "The Tonight Show with Jay Leno" in January.
Cryer's "Two and a Half Men" co-star Melanie Lynskey said the couple is "adorable together."
"Lisa is adorable," said Lynskey. "She makes him so happy. He's a very funny guy, but he's also very sincere and sweet and she understands that side of him. They are very adorable together."
Joyner is Cryer's second wife. He has a 6-year-old son, Charlie, with his first wife, Sarah Trigger.
"My son is just the happiest thing in my life," Cryer said in a 2006 interview. "I'm loving being a daddy, and ... Lisa and I are really looking forward to watching him grow."