Bello will portray Evelyn Carnahan O'Connell, the role played by Weisz in the first two "Mummy" movies, Variety reported Monday. Weisz had opted not to take part in the third installment.
Bello's recent films include "A History of Violence" and "Flicka." She has two new films ready for release, "The Jane Austen Book Club" and "Butterfly on a Wheel."
The storyline has the O'Connells and their full-grown son (Ford) traveling to the forbidden tombs of China and the Himalayas, where they encounter a shape-shifting mummy, a former Chinese emperor (Li) cursed by a wizard (Yeoh).
The first two "Mummies" filled Universal's coffers with more than $830 million.
Notable deaths of 2014 [PHOTOS]