The club's last show will feature performances by Hymns, Bow Thayer & the Perfect Train Wreck and Amanda Kravat.
"Fittingly, these acts follow in the Sin-e's tradition of giving a voice to emerging musicians while celebrating the energy of the NYC scene," Sin-e said in a news release. No reason was given for the closure.
A message on the club's Web site said simply: "To all the bands, booking agents, staff, friends and patrons... Thank you."