"This is the first time I've been up here to receive anything," a tearful Blige said as she accepted the R&B Album of the Year award for "The Breakthrough." "Thank you so very much."
Later, she accepted the award for Best Female R&B Vocal Performance for "Be Without You," which also was named Best R&B Song.
Blige led all nominees this year with eight nominations.
John Legend earned Best Male R&B Vocal Performance for the track, "Heaven," from the "Once Again" album.