The film follows England's Queen Elizabeth II in the wake of Princess Diana's untimely death in a 1997 Paris car crash. Frears was named best director and "The Queen" screenwriter won for best screenplay.
"Dreamgirls" songbird Jennifer Hudson and "For Your Consideration" comedian Catherine O'Hara tied for best supporting actress, and Hudson won the breakthrough performer award.
The quirky family comedy "Little Miss Sunshine" -- starring Abigail Breslin, Steve Carell, Toni Collette, Greg Kinnear and Alan Arkin -- won the for best ensemble cast. Its directors, Jonathan Dayton and Valerie Faris, won for best director debut.
The NYFCO's 26 members also honored Philip Glass for his score and Dick Pope for cinematography for "The Illusionist."
"Happy Feet" won for best animated feature. "An Inconvenient Truth" was named best documentary. "Pan's Labyrinth" won for best foreign language picture.