She will be joined by Julianna Margulies, Liev Schreiber, Nia Vardalos, Rosie Perez, David Cross, Sam Rockwell, Erika Christensen as well as others in the one-night-only benefit, the New York Post reported Monday.
The show, at the American Airlines Theatre in New York, is a benefit for the Working Playground, a nonprofit cultural organization that supports arts programs in New York City public schools.
The actors performing in six 10-minute plays will only have one day to prepare themselves for the stage.
The previous 24 Hour Plays show that the results will probably be wildly uneven, with some doing well and others not.
Notable deaths of 2014 [PHOTOS]
Mindy Kaling mistaken for Malala Yousafzai