The actor said he believes he is prepared for the physicality of the role, once filmmakers George Lucas and Steven Spielberg complete the screenplay, the BBC reported.
"I think it's a real opportunity to make a film as successful as the ones we've made before," said Ford.
The "Indiana Jones" trilogy scored blockbuster grosses at the global box office and garnered seven Academy Award nominations.
Ford said he hoped actor Sean Connery would reprise his "Indiana Jones and the Last Crusade" role as Indiana Jones' father.
"He's part of the emotional fabric of these films. I believe that Sean is still willing and I'd be delighted if he joined us," he told the BBC.
Connery, who was at the Rome event last week, said no offer had been made, the BBC said.