"It's all about musicianship and people who are positive," says Mustaine, who started the heavy metal package tour in 2005. "We want people out there who aren't afraid to do a guitar solo, and with the guys from Lamb of God, Opeth, Arch Enemy and the other bands, we have a great new generation of guitar players out there."
The Gigantour 2006 lineup also includes Arch Enemy, Overkill, Into Eternity, Sanctity and the Smashup.
The tour begins Wednesday near Boise, Idaho, and plays 25 dates into early October. Three Australian dates are set for late October.
The inaugural Gigantour, which also featured Dream Academy and Fear Factory, spawned CD and DVD releases.