The episode starts filming in New York Friday, the New York Post reported Monday.
In the episode called "Uncle," police arrest Andrew Munch as a suspect in a murder case. The episode will air next fall, the Post said.
Although he is best known for his comedies, Lewis, 80, received rave reviews for his dramatic turn in Martin Scorsese's 1983 film, "The King of Comedy."
Celebrity Families of 2014 [PHOTOS]