The Emmy-winning thriller starring Jennifer Garner as agent Sydney Bristow will air its final episode in May, ABC announced late Wednesday.
E! Online said "Alias" had fallen prey to the "Mork and Mindy" curse.
ABC has not been able to maintain a scripted TV show in the 8 p.m. Thursday slot since "Mork & Mindy" was canceled in 1982, E! said.
"Alias" joins "My So Called Life," "Threat Matrix" and "Knightwatch" in ABC's Thursday night graveyard.
Exploding whale video goes viral on Internet
Jordana Brewster on Paul Walker: 'He was an enormous presence in my life'