The magazine's 10th annual Man of the Year cover is a topless Aniston, with her womanly parts discretely obscured, Zap2it.com reported Tuesday.
The magazine said it decided to forgo the Y gene and chose Aniston this year for her "poise, grace and humor" during the scandal involving her now ex-husband Brad Pitt and his girlfriend, Angelina Jolie.
The magazine named two other Men of the Year -- Aniston's co-star in "The Break Up," Vince Vaughn, and rapper/actor 50 Cent.
The magazine will hit newstands Nov. 22 with covers of each of their honorees.
Notable deaths of 2014 [PHOTOS]
Polly Bergen, Emmy Award-winning actress, dies