Her latest book, "Christ the Lord: Out of Egypt," is about the 7-year-old Jesus, written in his own voice, she told Newsweek magazine.
Rice, 65, said a health scare sent her back to the Catholic Church and "I promised that from now on I would write only for the Lord."
Rice, whose 25 books have sold 136 million copies, said she "was in despair" when she wrote "Interview with a Vampire" and her other otherworldly tomes.
Although she will most likely lose some readers with her new direction, others may find Jesus satisfies their spiritual needs better than the vampire Lestat, she said.
In the afterward of "Christ the Lord: Out of Egypt" Rice calls her subject "the ultimate supernatural hero. The ultimate immortal of them all."