"We're kind of in the same place at the same time," says Eric Clapton, who formed the group in 1966 with Jack Bruce and Ginger Baker. Cream released four albums before breaking up in 1968.
"We were feeling like it would be good to do something worthwhile, not just leave that as a memory," Clapton adds. "When everyone was still available to do it, why not?"
Before this year, Cream's only public performance since breaking up was at its 1993 Rock and Roll Hall of Fame induction. The trio reunited for shows in May in England, which yielded the CD and DVD set "Royal Albert Hall London May 2-3-5-6 2005."
Cream will play Oct. 24-26 at Madison Square Garden. No other shows have been announced.