The cover of the Oct. 17 issue features Ty Pennington of "Extreme Home Makeover: Home Edition."
TV Guide Publishing Group President Scott Crystal hailed the expansion from a pocket-size publication to a full-sized magazine as a "historic transformation."
The changes were made in response to reader's demands, he said.
The new TV Guide sells for 99 cents until year's end, then goes up to $1.99 starting in 2006.
The magazine currently has a paid circulation about about 4.5 million, TV Guide said in a news release.