Simpson will sign autographs and photos starting at $95 a pop during the NecroComicon Friday through Sunday in the Los Angeles suburb of Northridge, Calif.
The NecroComicon will mark Simpson's first Los Angeles public appearance since the slayings, convention officials said in a news release.
Co-promoter Thomas Riccio said Simpson was invited to the event because he is "arguably the best football player who ever lived. He's a Heisman Trophy Winner, a former All American, an NFL M.V.P., and a Pro-Football Hall Of Famer."
He said thousands of sports memorabilia collectors have been waiting more than a decade for a chance to get Simpson's autograph.