Knoxville, Scott and Simpson will host a screening of the movie and spend time with service members and their families Wednesday.
The three stars will tour facilities, visit spouses and children of deployed military members, pose for pictures and shake hands with military personnel, according to the United Service Organizations, or USO.
Knoxville, Scott and Simpson also will visit troops Tuesday at Robins Air Force Base, Ga., while Willie Nelson joins Simpson at the U.S. Marine Corps Air Station in Miramar, Calif., Friday.
The film, based on the 1970s television series "The Dukes of Hazzard," follows Duke cousins Bo, played by Scott, and Luke, played by Knoxville, on a mission to save their family farm from Hazzard County's corrupt county commissioner Boss Hogg, played by Burt Reynolds.
The film is scheduled to open in the United States Aug. 5.